Research
Because no cure exists for OI, current treatment is aimed at preventing or correcting symptoms. At Kennedy Krieger Institute, however, research on improving current treatment regimes and understanding the natural history of OI is well under way. A sampling of our research topics and interests include:
The utilization and efficacy of physical therapy services for individuals with Osteogenesis Imperfecta
Summary:
To determine how physical therapy services are being used by individuals with OI and how adequate these services are for individuals with OIStatus:
OngoingPublication:
Not begun yet
Assessment of Medical and Surgical Aspects of Cardiovascular Disease in OI
Summary
To access the incidence and clinical characteristics of cardiovascular disease and its surgical treatment in adults with OI.Status
OngoingPublication
Not begun yet
Distal Femur Bone Mineral Density Measurements in Healthy Individuals and Individuals with Acquired and Genetic Bone Disorder
Summary
To assess the DXA bone density measurement at the distal femur and femur neck in three adult populations: healthy volunteers, OI patients and Spinal Cord Injury patients.Status
Pending IRB approvalPublication
Not begun yet
The IBMD-OI Study
A Study to Assess the Effectiveness of Teriparatide (FORTEO) for Increasing Bone Mass and Improving Bone Structure in Adults Affected with Osteogenesis Imperfecta (OI).
Summary
FORTEO is approved by FDA for the treatment of osteoporosis. A clinical trial to assess if Forteo has any benefit for adults with OI. Adults will self-inject over an 18-month period and visit the OI Clinic every 3 months to be assessed.Status
Data analysis is in progress.Publications
Pending
The Impact of Nutrition on Bone Growth in Osteogenesis Imperfecta.
Summary
A clinical trial to assess the impact of nutrition factors on bone growth in children aged 2-10 with OI. Children will be followed for nutritional intake and given functional assessments at each visit.Status
Ongoing.Publications
Not begun yet.
Bisphosphonate Treatment in Adults with Osteogenesis Imperfecta
Summary
A retrospective chart review to assess the effect of bisphosphonate use in adults with OI.Status
CompletedPublications
Shapiro JR, Thompson CB, Wu Y, Nunes M, Gillen C. Bone mineral density and fracture rate in response to intravenous and oral biphosphonates in adult osteogenesis imperfecta. Calcif Tissue Int. 2010 Aug; 87(2): 120-9.
Bisphosphonate Treatment in Children with Osteogenesis Imperfecta
Summary
A retrospective chart review to assess the effect of bisphosphonate use in children with OI.Status
Pending IRB approval.Publications
Not begun yet.
The Osteogenesis Imperfecta Linked Clinical Research Centers
Summary
To assess the natural history of OI over 5 years for 100 individuals with OI.Status
ongoingPublications
Publications will wait for data acquisition.
The Osteogenesis Imperfecta Registry
Summary
To provide an up-to-date listing of individuals with OI, and to connect individuals with clinical investigators researching topics in OI.Status
Ongoing.Presentations
"The Characteristics of the Osteogenesis Imperfecta Registry Population": The Western Regional Meeting, January 2010 and "The Osteogenesis Imperfecta Registry": The U.S. and Taiwan Osteogenesis Imperfecta Symposium, May 2011.
Type V Osteogenesis Imperfecta
Summary
To assess the impact of nutrition factors on bone growth in children aged 2-10 with OI.Status
Pending publicationPublications
Publication in progress
If you would like to collaborate or dialogue regarding research endeavors or potential topics relevant to OI research, please contact us. We look forward to hearing from you and assisting you with your OI research efforts.
- Contact Us
- The Osteogenesis Imperfecta Clinic
- 801 North Broadway
- Baltimore, MD 21205
- 443-923-9400