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Because no cure exists for OI, current treatment is aimed at preventing or correcting symptoms. At Kennedy Krieger Institute, however, research on improving current treatment regimes and understanding the natural history of OI is well under way. A sampling of our research topics and interests include:

The IBMD-OI Study

A Study to Assess the Effectiveness of Teriparatide (FORTEO) for Increasing Bone Mass and Improving Bone Structure in Adults Affected with Osteogenesis Imperfecta (OI).

• Summary

   FORTEO is approved by FDA for the treatment of osteoporosis. A clinical trial to assess if Forteo has any benefit for adults with OI. Adults will self-inject over an 18-month period and visit the OI Clinic every 3 months to be assessed.

• Status

   Ongoing.

• Publications

   Not begun yet.

The Impact of Nutrition on Bone Growth in Osteogenesis Imperfecta.

• Summary

   A clinical trial to assess the impact of nutrition factors on bone growth in children aged 2-10 with OI. Children will be followed for nutritional intake and given functional assessments at each visit.

• Status

   Ongoing.

• Publications

   Not begun yet.

Bisphosphonate Treatment in Adults with Osteogenesis Imperfecta

• Summary

   A retrospective chart review to assess the effect of bisphosphonate use in adults with OI.

• Status

   Pending completion.

• Publications

   Pending submission.

Bisphosphonate Treatment in Children with Osteogenesis Imperfecta

• Summary

   A retrospective chart review to assess the effect of bisphosphonate use in children with OI.

• Status

   Pending IRB approval.

• Publications

   Not begun yet.

NTx and Alkaline Phosphatase Response to Bisphosphonate Treatment in Adult Osteogenesis Imperfecta

• Summary

   A retrospective chart review to identify any patterns in NTX and alkaline phosphatase scores in adults with OI.

• Status

   Ongoing.

• Publications

   Not begun yet.

The Osteogenesis Imperfecta Linked Clinical Research Centers

• Summary

   To assess the natural history of OI over 5 years for 100 individuals with OI.

• Status

    ongoing

• Publications

   Not begun yet.

The Osteogenesis Imperfecta Registry

• Summary

   To provide an up-to-date listing of individuals with OI, and to connect individuals with clinical investigators researching topics in OI.

• Status

   Ongoing.

• Publications

   Pending.

Assessment of Vitamin D Deficiency in Osteogenesis Imperfecta

• Summary

   To assess the degree of vitamin D deficiency in children with OI.

• Status

   Completed.

• Publications

   Not begun yet.

Poster (Presented at the ASBMR Conference 2007; Honolulu, Hawaii)

Bisphosphonate Treatment of Cerebral Palsy

• Summary

   To assess the impact of bisphosphonate treatment in individuals with cerebral palsy.

• Status

   Pending Publication.

• Publications

   Pending Publication.

Poster (Presented at the AAPM&R Conference in 2008; San Diego, CA)

Type V Osteogenesis Imperfecta

• Summary

   To assess the impact of nutrition factors on bone growth in children aged 2-10 with OI.

• Status

   Pending analysis.

• Publications

   Pending write-up.

If you would like to collaborate or dialogue regarding research endeavors or potential topics relevant to OI research, please contact us. We look forward to hearing from you and assisting you with your OI research efforts.

• Contact Us
• The Osteogenesis Imperfecta Clinic
• 801 North Broadway
• Baltimore, MD 21205
• 410-923-9400